Collagen-Induced Arthritis Suppressed with Monoclonal Anti-Idiotypic Antibody

Restricted expression of anti-type II collagen antibody isotypes in mice suppressed for collagen-induced arthritis.

The present study details the time course and isotype distribution of the immune response to type II collagen in collagen-induced arthritic mice and mice suppressed for collagen-induced arthritis. The serum of arthritic mice was observed to contain significantly higher (p less than 0.005) concentrations of antibodies to type II collagen than that of mice suppressed for arthritis at all times te...

Is Associated with Induction of LAP Attenuates Collagen-Induced Arthritis That Mucosal Anti-CD3 Monoclonal Antibody

Collagen Antibody Induced Arthritis

Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.

Activated components of the complement system are potent mediators of inflammation that may play an important role in numerous disease states. For example, they have been implicated in the pathogenesis of inflammatory joint diseases including rheumatoid arthritis (RA). To target complement activation in immune-mediated joint inflammation, we have utilized monoclonal antibodies (mAbs) that inhib...

Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody.

Syngeneic monoclonal anti-idiotope antibody Ab2,2-17C3SCC was raised against an idiotope on a protective monoclonal antibody with specificity for poliovirus type II. Ab2,2-17C3SCC detects a paratope-related interspecies IdX. Ab2,2-17C3SCC purified from supernatant fluids of hybridoma cells by protein A-Sepharose was injected into 4- to 6-wk-old BALB/c mice. The sera of the mice were screened fo...